The night owl’s disease problem

A new study has an important message for night owls. Investigators from Harvard-affiliated Brigham and Women’s Hospital found that people with later sleep and wake times had less-healthy lifestyles and were at greater risk of developing diabetes than those with early bird habits. The results are published in the Annals of Internal Medicine.

“Chronotype, or circadian preference, refers to a person’s preferred timing of sleep and waking and is partly genetically determined so it may be difficult to change,” said corresponding author Tianyi Huang, an assistant professor of medicine at Harvard Medical School and an associate epidemiologist in the Brigham’s Channing Division of Network Medicine. “People who think they are night owls may need to pay more attention to their lifestyle because their evening chronotype may add increased risk for Type 2 diabetes.”

The researchers previously found that people with irregular sleep schedules were at higher risk of developing diabetes and cardiovascular disease and that people with evening chronotypes were more likely to have irregular sleep patterns. For this study, they wanted to understand the relationship between chronotype and diabetes risk and looked at the role of lifestyle factors as well.

The team analyzed data from 63,676 female nurses from the Nurses’ Health Study II collected from 2009 to 2017 and included self-reported chronotype (the extent to which participants perceived themselves to be an evening person or a morning person), diet quality, weight and body mass index, sleep timing, smoking behaviors, alcohol use, physical activity, and family history of diabetes. The team determined diabetes status from the participants’ self-reports and medical records.

“Chronotype, or circadian preference, refers to a person’s preferred timing of sleep and waking and is partly genetically determined so it may be difficult to change.”

The Nurses’ Health Study II, a joint effort between the Channing Division and the Harvard T.H. Chan School of Public Health, is among the largest investigations into risk factors for major chronic diseases in women. One of the study’s strengths is its regular follow-up of participants and repeated assessment of health and lifestyle factors.

Approximately 11 percent of participants reported having a “definite evening” chronotype and about 35 percent reported having “definite morning” chronotype. The remaining population were labeled as “intermediate,” meaning they either identified as being neither a morning nor evening type or as being only slightly more one than the other.

The evening chronotype was associated with a 72 percent increased risk for diabetes before accounting for lifestyle factors. After accounting for lifestyle factors, evening chronotype was associated with a 19 percent increased risk of diabetes. Among those in the study with the healthiest lifestyles, only 6 percent had evening chronotypes. Among those with the unhealthiest lifestyles, 25 percent were evening chronotypes.

Those with evening chronotypes were found to be more likely to drink alcohol in higher quantities, have a low-quality food diet, get fewer hours of sleep per night, currently smoke, and have weight, BMI, and physical activity rates in the unhealthy range.

“When we controlled for unhealthy lifestyle behaviors, the strong association between chronotype and diabetes risk was reduced but still remained, which means that lifestyle factors explain a notable proportion of this association,” said first author Sina Kianersi, a postdoctoral research fellow in the Channing Division.

They also found the association between evening chronotype and diabetes risk only in those nurses who worked day shifts and not those who worked overnight shifts.

“When chronotype was not matched with work hours we saw an increase in Type 2 diabetes risk,” said Huang. “That was another very interesting finding suggesting that more personalized work scheduling could be beneficial.”

The Nurses’ Health Study is made up mainly of white female nurses — future investigations will be needed to determine if the patterns detected here are consistent across populations. The study’s results point to associations but cannot determine causality.

Next, the researchers plan to investigate genetic determinants of chronotype and its association with cardiovascular disease, in addition to diabetes, in larger, more diverse populations.

“If we are able to determine a causal link between chronotype and diabetes or other diseases, physicians could better tailor prevention strategies for their patients,” says Kianersi.

The study was funded by the National Institutes of Health.

A co-author reports consulting fees from ApniMed Inc., Eli Lilly, and Jazz Pharma and receipt of equipment for use in multicenter NIH research from Philips Respironics and Nox Medical.